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TVX was withdrawn from the market in 1999 after the occurrence of 140 severe adverse hepatic events and 14 cases of acute liver failure in human patients 18 , without indicating these side effects in mice studies 19

This highlights the pressing need to combat anti-microbial resistance through pioneering discovery platforms that have the potential of extending chemical access, finding new bacterial weaknesses, and considering the evolutionary dynamics at the early stages of development

It is mostly absorbed in the small intestine and colon

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